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KMID : 1147720210140040167
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Journal of Acupuncture and Meridian Studies
2021 Volume.14 No. 4 p.167 ~ p.172
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Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Reflex in Rats
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Yamashita Hiromi
Zeredo Jorge Luis Lopes
Toda Kazuo
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Abstract
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Background: Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient’s age on the effectiveness of electroacupuncture treatment has not been clearly established.
Objectives: The present study aimed to detect a potential difference in electroacupuncture- induced analgesia between juvenile and adult rats.
Methods: In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats.
Results: Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats.
Conclusion: These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats.
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KEYWORD
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Jaw-opening reflex, Tooth pulp, Electroacupuncture, Age, Naloxone, Rat
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